Design, Development and Optimization of Topotecan Hydrochloride Solid Lipid Nanoparticles for Oral Chemotherapy

SLNs are sub-micron colloidal carriers ranging from 50 to 1000 nm, which are composed of physiological lipid, dispersed in water or in aqueous surfactant solution [2,3]. They offer unique properties such as small size, large surface area, high drug loading and are attractive for their potential to improve performance of pharmaceuticals [4-6]. Furthermore, they also have the ability to encapsulate both hydrophobic and hydrophilic drugs, improving thus their physico-chemical and pharmacokinetics profile [1,5]. Solid lipid nanoparticles have many advantages namely low cost of ingredients, ease of preparation and scale-up, high drug payload, no biotoxicity of the carrier, possibility of controlled drug release and targeting [5,6].